Permeability barrier requirements regulate epidermal beta-glucocerebrosidase.
نویسندگان
چکیده
منابع مشابه
Hypothesis: the epidermal permeability barrier is a porous medium.
The stratum corneum is a complex biological material characterized by very low permeability to water and most other molecules. This material may be thought of as a 'porous medium' composed of impermeable and permeable regions. Intercellular lipid membranes in the stratum corneum are postulated to exist in a mixture of two phases: solid (i.e. impermeable) and liquid crystalline (permeable). The ...
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Background/Objectives: Prior studies have demonstrated that both the skin surface pH and epidermal permeability barrier function vary with skin pigmentation types. Although melanin deficiency is the main feature of vitiligo, alterations in cutaneous biophysical properties in vitiligo have not yet been well defined. In the present study, stratum corneum (SC) hydration, the skin surface pH and ep...
متن کاملPhysical and Chemical Factors that Improve Epidermal Permeability Barrier Homeostasis
For terrestrial creatures, the water-impermeable barrier function of the skin is essential to maintain life in the face of environmental dryness. Stratum corneum, which plays a crucial role in the barrier function, is composed of two components, i.e., protein-rich nonviable cells and intercellular lipid domains. When the barrier function is damaged by a surfactant, organic solvent or tape strip...
متن کاملThe Role of Epidermal Lipids in Cutaneous Permeability Barrier Homeostasis
The permeability barrier is required for terrestrial life and is localized to the stratum corneum, where extracellular lipid membranes inhibit water movement. The lipids that constitute the extracellular matrix have a unique composition and are 50% ceramides, 25% cholesterol, and 15% free fatty acids. Essential fatty acid deficiency results in abnormalities in stratum corneum structure function...
متن کاملEpidermal Permeability Barrier in the Treatment of Keratosis Pilaris
Objectives. To evaluate and compare the efficacy, safety, hydrating properties, and tolerability of 10% lactic acid (LA) and 5% salicylic acid (SA) in the therapy of keratosis pilaris (KP). Material and Method. Patients with KP were randomized for treatment with either 10% LA or 5% SA creams being applied twice daily for 3 months. The patients were clinically assessed at baseline and after 4, 8...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1994
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)39184-7